As the year comes to its end, our epigenetic clocks keep on ticking, and hot new DNA methylation-based studies keep rolling in. Here, we gaze into two deeply interesting studies that take us on an epigenetic journey from deep space to deep learning by reporting how space travel can influence epigenetic aging and how neural […]

While the cough was the cardinal consideration, COVID-19 has been causing chaos in every organ system, including lungs, heart, brain, blood, liver, and skin. In fact, the involvement of these non-lung systems predicts increased mortality and new research now shows that DNA methylation is a contributor to COVID-19. Researchers from the laboratory of Arjun Deb […]

Back in the days of big hair and masses of leather, Cher wanted to “turn back time” if she could find a way! Well, get your stockings and suspenders ready and head for the docks, as her eighties “vision” may be on the cusp of coming true with the help of epigenetic reprogramming! Specifically, resear-Cher-s […]

Although studies of DNA methylation and its impact on chromatin architecture leave us with quite the buzz, this latest one adds a bit of cocaine to the mix to give it an extra kick. This stimulating study found cocaine use reduced DNA methylation at a key gene to change CTCF binding and alter 3D chromatin […]

While “toxic masculinity” may seem intimately linked to the human species, the fruit fly Drosophila has come to show us that their Y-chromosome acts as a source of genomic male “toxicity” that epigenetic silencing keeps in check. Specifically, we know that the formation of silent heterochromatin domains during development represses the activity of transposable elements […]

虽然DNA甲基化和明显的RNA物种在持续的父目遗传遗传的持续故事中遭到了敏捷，但是遗传小鼠模型现在将组蛋白甲基化作为这种抓住转基因故事中的主要球员施放。通过Sarah Kimmins（McGill University，Canada，Canada）领导的前一项研究发现，在[...]中，将H3赖氨酸4个二甲基化（H3K4ME2）降低

If there’s one thing we can all agree on, it’s that mitochondria are the powerhouse of the cell. Adding to this prowess is a new finding showing that the amount of mitochondrial DNA impacts nuclear DNA methylation and gene expression, ultimately influencing mortality and cardiovascular disease. While we’ve seen how mutant mitochondria can influence histone […]

While stories of Mom meeting Dad often leave their mark on a family, and sometimes a nation, the plot has now thickened thanks to new findings showing that Mom’s DNMT3A leaves its mark on Dad’s genome in the early embryo. DNA methylation in the male germline undergoes massive changes during preimplantation. High paternal DNA methylation […]

As the year comes to its end, our epigenetic clocks keep on ticking, and hot new DNA methylation-based studies keep rolling in. Here, we gaze into two deeply interesting studies that take us on an epigenetic journey from deep space to deep learning by reporting how space travel can influence epigenetic aging and how neural […]

While the cough was the cardinal consideration, COVID-19 has been causing chaos in every organ system, including lungs, heart, brain, blood, liver, and skin. In fact, the involvement of these non-lung systems predicts increased mortality and new research now shows that DNA methylation is a contributor to COVID-19. Researchers from the laboratory of Arjun Deb […]

Although studies of DNA methylation and its impact on chromatin architecture leave us with quite the buzz, this latest one adds a bit of cocaine to the mix to give it an extra kick. This stimulating study found cocaine use reduced DNA methylation at a key gene to change CTCF binding and alter 3D chromatin […]

While “toxic masculinity” may seem intimately linked to the human species, the fruit fly Drosophila has come to show us that their Y-chromosome acts as a source of genomic male “toxicity” that epigenetic silencing keeps in check. Specifically, we know that the formation of silent heterochromatin domains during development represses the activity of transposable elements […]

If there’s one thing we can all agree on, it’s that mitochondria are the powerhouse of the cell. Adding to this prowess is a new finding showing that the amount of mitochondrial DNA impacts nuclear DNA methylation and gene expression, ultimately influencing mortality and cardiovascular disease. While we’ve seen how mutant mitochondria can influence histone […]

While stories of Mom meeting Dad often leave their mark on a family, and sometimes a nation, the plot has now thickened thanks to new findings showing that Mom’s DNMT3A leaves its mark on Dad’s genome in the early embryo. DNA methylation in the male germline undergoes massive changes during preimplantation. High paternal DNA methylation […]

我们的赞助商帮助您保持灯光，Wi-Fi嗡嗡声，以及我们每周流入屏幕的表观遗传含量。虽然我们可能是一个偏见的TAD，但我们希望从这些网站上转向非常有用，始终是教育表观遗传学内容的聚光灯！燕尾基因组学[...]

Combinations of old favorites can be even tastier than the sum of their parts. Who doesn’t leave peanut butter and jam, chips and dip, and DNA methylation and chromatin assays? While they sound appetizing, those last two aren’t quite as easy to get together. Many assays have been developed in the past to combine ChIP […]

While a “bird’s-eye view” of a topic can often provide colossal insight, the opposite perspective can sometimes be just as useful! Recently, two fascinating studies of transgenerational epigenetic inheritance have taken a “worm’s-eye view” of this research area to deepen our understanding of this complex mechanism in the model nematode worm C. elegans. C. elegans […]

When it comes to X inactivation there are a huge number of studies that eXist. Despite being one of the best-studied epigenetic phenomena, the molecular decision making process behind the initiation of X chromosome inactivation (XCI) had remained far from fully understood. The regulation of the long non-coding RNA Xist initiates XCI. Xist’s antisense partner […]

Move over, Rogaine; the pharmacies of the future will carry hair regrowth treatments that contain microRNAs from hair follicle exosomes! There are creams, supplements, lasers and even surgery, but people struggling with hair loss still don’t have a convenient and effective treatment to help them restore their luscious locks. New treatments could involve injecting dermal […]

For the last few years, DNA has cornered the methylation market as the Apple of epigenome editing tools, but a newly developed CRISPR-Cas13 system has epigenetic investors buying stock in RNA editing! 6-methyladenosine (m6A) is the most abundant RNA modification, and even though we know it’s involved in chromatin accessibility, RNA splicing and repairing damaged […]

While missing a gym class can happen from time to time without leaving you feeling too guilty (!), you really shouldn’t “skip” a fascinating new study that now describes how a maternally-transmitted epigenetic “exon skipping” effect may act as the foundation for new therapeutic approaches for a devastating genetic muscle-weakening disease. A majority of Duchenne […]

While the sprawls of London and Paris take center stage in the novel “A Tale of Two Cities,” we now seek to narrate an alternative epigenetic “tail” that tells all about two nucleotides! In this hefty tome, uridine and guanosine play the starring roles in a story passed down through generations and generations of worms; […]

队列！安全！丢失的护照！虽然许多人目前将回忆在旧假期享受的乐趣和嬉戏，但我们通常会选择忘记外出旅程的持久压力。然而，令人迷人的新研究现在提供了证据表明，通过在他们的史诗航行期间通过成熟的精子持续的任何压力是[...]

当它是冬天的死亡时，外面的世界被冻结了，没有比在温暖的毯子下的山下的更好的地方，就像XIST长的RNA云下的灭活X染色体一样。虽然我们已知一段时间虽然该Xist是X染色体灭活（XCI）所必需的，但机制[...]

For the last few years, DNA has cornered the methylation market as the Apple of epigenome editing tools, but a newly developed CRISPR-Cas13 system has epigenetic investors buying stock in RNA editing! 6-methyladenosine (m6A) is the most abundant RNA modification, and even though we know it’s involved in chromatin accessibility, RNA splicing and repairing damaged […]

While the crisper drawer of our fridge is the best way to keep our produce fresh, epigenetic editing research now brings forth CRISPR-based manipulation of DNA methylation to keep our crops crisp. This tasty treat comes at you in the form of two new publications from the lab of Steven Jacobsen (UCLA), where the talented team expand […]

While even a technology with a future as bright as epigenome editing can have its cold day in the sun, the Suntag system has just cleared the clouds over a growing pain of epigenetic editing: the global off-target effects of dCas9-DNMT3A direct fusion constructs. To cure our epigenetic editing blues, the lab of Ryan Lister […]

救援行动的呼吁通常会使人类转向最新和最大的工具和设备。无论是与水射流还是尖端的表观编辑技术的消防员，这些日子都没有容易的人类威胁。亚博pc在他们的最新报告中，鲁道夫Jaenisch实验室的表观遗传应急响应团队和[...]

虽然我们已经被通过停用CAS9（DCAS9）的精确表观遗传编辑的强大应用所迷住，但我们也被介于表观遗传编辑并不总是按预期工作的事实。建立我们需要退后一步，看看亚历山大·梅斯纳的实验室的更大的画面，在[...]

While a hit-and-run typically leads to an arrest, in the world of epigenetic editing it turns out to be the key to evading cell cycle arrest (senescence) and promoting the transformation of a law-abiding cell into a cancerous criminal! The hypermethylation of promoters at the wrong time and wrong place is a trademark of cancer, […]

Many studies have put their faith in CRISPR-Cas9 as a means to edit genes in human embryos, to fight HIV, and to explore epigenetic regulation. However, if you are someone who really needs to see CRISPR-Cas9 in action to believe it, an epic new study has you covered! So, cast away those doubts and qualms, […]

处理微卫星疾病的令人困难的是射击实际卫星，但由于DCAS9变得更容易。CRISPR / CAS9系统已被证明不仅仅是一副剪刀。例如，CRISPR干扰（CRISPRI）使用Deactivated Cas9（DCAS9）来为扰动基因表达产生特定于特定的空间阻碍。[...]

CpG islands have been the best-known tourist destination in the epigenome for a long time, but if you’re looking for a change there’s a destination that all the rage: DNA methylation grand canyons. It is well known that DNA methylation at CpG islands is associated with transcriptional repression. However, the precise molecular mechanism linking DNA […]

全基因组染色体构象捕获分析es, such as Hi-C, have provided us with snapshots of the large-scale spatial architecture of mammalian genomes, describing chromatin compartments, topologically associating domains (TADs), and CTCF– and cohesin-mediated chromatin loops in many cell types. However, the resolution of Hi-C-based protocols, limited by the size and uniformity of chromatin fragmentation, represents a […]

亚硝系统，改进的空气动力学，在您的车上和幻灯片轮胎可能会帮助淬火当你落后轮子时的速度;但是，在基因监管的世界中，需要放缓的必要性。最近，研究人员团队描述了如何修改Racy子集[...]

A weekend away with a book of poetry, a mountain biking holiday, or perhaps a daring jewel heist……whatever your idea of a fun weekend is, a well-laid out, precise set of instructions usually help; in short, you need a plan! In the gastrulating mouse embryo, precise epigenomic and transcriptomic instructions dictate the differentiation of pluripotent […]

从加州理工学院的Ellen Rothenberg博士将她的实验室研究了2019年联合Ceehrc / IHE亚博pcC会议的T细胞发展的外观遗传学研究。

Dr. John Greally from the Albert Einstein College of Medicine discusses his group’s research into the epigenomics of human health at the 2019 joint CEEHRC/IHEC meeting.

The Jurassic Park movies got the whole world excited about resurrecting dinosaurs from fossilized DNA, but more recent findings that the half-life of DNA is only 521 years mean that dream is science fiction. So, while the finer details of dinosaur genomes may be lost in the fossil record, new work has dug up epigenomic […]

虽然CRISPR / CAS9系统的DNA编辑功能可能看起来可能会呕吐燃烧，但我们相信CRISPR / CAS9介导的诱导多能干细胞（IPSC）的新的SunTAG方法通过外膜内的编辑重编程值得其在阳光下的一天！令人兴奋的重编程策略利用内切核酸酶死Cas9（DCAS9）融合到已知的重复蛋白质支架[...]

As the year comes to its end, our epigenetic clocks keep on ticking, and hot new DNA methylation-based studies keep rolling in. Here, we gaze into two deeply interesting studies that take us on an epigenetic journey from deep space to deep learning by reporting how space travel can influence epigenetic aging and how neural […]

Back in the days of big hair and masses of leather, Cher wanted to “turn back time” if she could find a way! Well, get your stockings and suspenders ready and head for the docks, as her eighties “vision” may be on the cusp of coming true with the help of epigenetic reprogramming! Specifically, resear-Cher-s […]

Scientists are always working against the clock, and recently, a team led by Wolfgang Wagner (RWTH Aachen University, Germany) used their ever-evaporating time to explore a potential link between telomere shortening and epigenetic clock acceleration in premature-aging associated bone marrow failure syndromes and describe a new disease biomarker! Patients with premature aging and difficult-to-diagnose bone […]

他们说你不能教一只老狗的新技巧，但事实证明你可以使用新的表观胸肉技巧来告诉你一只狗的年龄。让狗年龄在人类年龄的启发式，你乘以七个是一点简单化，并且由于使用表观胸肉洞察力的更新。[...]

虽然我们希望我们形成岁月的任何愚蠢的错误和幼稚的恶作剧不遵循美国成年期，但现在似乎在早期发展的某些经历确实被录制到了已于已经我们的知识，激活触发器可能导致麻烦和争吵！！具体而言，在[...]期间接触任何数量的环境压力

“司机”代表成功的一级团队的关键部分，高尔夫球场的体面得分，甚至是一个规划良好的银行血统（！），并制定那些推动各种疾病和疾病发作的因素可能提供批判性机械洞察力甚至援助新型治疗方法的发展。在早期开始[...]

他们说后来是20/20，但对于我们那些俯视了一生的回忆，事情可能似乎是我们的老化眼睛。那是因为，与美味的葡萄酒，美味的威士忌和臭味奶酪不同，我们喜欢分发，人的表观蛋白酶往往没有成年，并且很广泛[...]

In the last 50 years, there has been a ~20% increase in global life expectancy but interestingly, there has not been a corresponding increase in the number of healthy years lived. Lubin Jiang and Shi-Qing Cai at the Chinese Academy of Sciences (Shanghai, China) sought to understand that disparity by examining the genetic factors involved […]